Effect of some water-miscible organic solvents on the activity of acetylcholinesterase in nervous- and muscular tissues of Anodonta cygnea L. (Pelecypoda)

Varanka, István (1968) Effect of some water-miscible organic solvents on the activity of acetylcholinesterase in nervous- and muscular tissues of Anodonta cygnea L. (Pelecypoda). A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 35. pp. 83-91. ISSN 0365-3005

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Abstract

The effect of the straight-chain alcohols of C₁₋₅ atomic numbers, of the aromatic bensil-alcohol, of the bi-valent glycol and tri-valent glycerine as well as th a t of the ether and acetone on the AChE-activitv of the homogenates of ganglia and adductor muscles of Anodonta cygnea L. was investigated. I t could be stated, that: a) with the concentrations used (0.3 ml solvent in a final volume of 5 ml) all agents - with the exception of ether, bensil-alcohol and pentanol increase AChE-activity in the homogenates of ganglia. b) All agents with the exception of n-propanol do not influence or inhibit the AChE-activity of the „tonic” and „phasic” part of the adductor muscles. c) Alcohols with C₁₋₃ atomic numbers increase AChE activity of homogenates of ganglia at low concentration and inhibit it at higher concentrations. d) The maximum of the activation shifts towards the lower concentration values with increasing Mol-weight of the alcohol respectively with its chain length, at the same time the degree of the maximum activation also increases. e) Author corroborates the conception that in the ganglia part of the active site of the enzyme is masked by a lipoid and supposes that in the adductor muscles the whole quantity of the enzyme is in active state, which may have functional consequences.

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