Adaptation of the heart of Helix pomatia L. to the inhibitory effect produced by extracardiac nerve

S.-Rózsa, Katalin (1966) Adaptation of the heart of Helix pomatia L. to the inhibitory effect produced by extracardiac nerve. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 33. pp. 125-133. ISSN 0365-3005

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Abstract

Author investigated the responses of the heart of Helix pomatia L. to long lasting and repeated stimulation of intestinal nerve. It was established that in case of long lasting and repeated nerve stimulation with inhibitory parameters the heart becomes liberated from the inhibiting effect, whereas at other parameters stimulating effect is demonstrable which is of unchanged intensity even in case of long lasting and repeated stimulation. The liberation of the heart from the inhibitory effects might be explained by the adaptation of acetylcholine receptors of protein nature. In case of 5-HT receptor of lipid nature an adaptation of this kind was not observed. Acridine orange which forms complexes with nucleotides and nucleic acids stops the inhibition produced by the intestinal nerve and makes it stimulatory even if the parameters are left unchanged. ATP restores the inhibitory effect. It is suggested that in the realization of inhibition produced by the intestinal nerve surface structures and primarily structural changes in the adenyl groups might be of importance.

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