The effect of 5-hydroxytryptamine on the heart of fresh water mussel (Anodonta cygnea L.) in the case of different modes of application

Pécsi, Tibor (1965) The effect of 5-hydroxytryptamine on the heart of fresh water mussel (Anodonta cygnea L.) in the case of different modes of application. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 32. pp. 55-67. ISSN 0365-3005

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Abstract

The effect on the heart of the fresh water mussel (Anodonta cygnea L.) of 5-hydroxytryptamine (5-HT) was examined with four modalities of application: a) given into the interior of the isolated heart, b) given into the bath liquid of the isolated heart, c) administered to the in situ heart or the pericardial liquid respectively and d) into the auricle of the in situ heart. It has been established that both in the case of isolated and in situ heart preparations the interior wall of the ventricle is more sensitive to 5-HT than the outer wall which must be absolutely taken into consideration when titrating 5-HT on the heart of lamellibranchiates and/or comparing data obtained with different methods. Under the experimental conditions, examining the interaction of the heart and of the rectum passing through it we demonstrated that the rectum does not disturb the response of the heart to low 5-HT concentrations, its effect appeared in high concentrations.

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