On the modulating effect of some biologically active substances in the central nervous system of molluscs

S.-Rózsa, Katalin (1965) On the modulating effect of some biologically active substances in the central nervous system of molluscs. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 32. pp. 69-75. ISSN 0365-3005

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Abstract

The modulating effect of some biologically active substances (serotonin, uridinediphosphate, noradrenaline, chlorpromazine) on the realization of stimuli arriving from the periphery was investigated in the central nervous system of Helix pomatia. The bioelectric activity of the pedal ganglion was registered; the agents were applied to the same ganglion at a concentration below threshold, the stimulation by water of the osmoreceptors located on the surface of the foot served as peripheric stimulus. It was established, that the realization of stimuli arriving from the periphery to the nerve center was facilitated by serotonin (1·10⁻¹¹ M) and uridinediphosphate (1·10⁻¹⁰ M) and depressed by noradrenaline (1·10⁻¹³ M) and chlorpromazine (1·10⁻⁹ M). Coclusions are drown as to the identity of mediators and modulators.

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