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Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study

Enyedy, Éva Anna and Primik, Michael F. and Kowol, Christian R. and Arion, Vladimir B. and Kiss, Tamás and Keppler, Bernhard K. (2011) Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study. DALTON TRANSACTIONS, 40 (22). pp. 5895-5905. ISSN 1477-9226

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Abstract

Stoichiometry and stability of GaIII, FeIII, FeII complexes of Triapine and five related α-N heterocyclic thiosemicarbazones with potential antitumor activity have been determined by pH-potentiometry, UV-vis spectrophotometry, 1H NMR spectroscopy, and spectrofluorimetry in aqueous solution (with 30% DMSO), together with the characterization of the proton dissociation processes. Additionally, the redox properties of the iron complexes were studied by cyclic voltammetry at various pH values. Formation of high stability bis-ligand complexes was found in all cases, which are predominant at physiological pH with FeIII/FeII, whilst only at the acidic pH range with GaIII. The results show that among the thiosemicarbazones with various substituents the N-terminal dimethylation does not exert a measurable effect on the redox potential, but has the highest impact on the stability of the complexes as well as the cytotoxicity, especially in the absence of a pyridine-NH2 group in the molecule. In addition the fluorescence properties of the ligands in aqueous solution and their changes caused by GaIII were studied.

Item Type: Article
Additional Information: Electronic supplementary information (ESI) available: Additional concentration distribution curves, UV-vis absorption, 1 H NMR, fluorescence (3D) emission and ESI-MS spectra with some cytotoxicity data. See DOI: 10.1039/c0dt01835j
Subjects: Q Science / természettudomány > QD Chemistry / kémia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 29 Jul 2024 13:57
Last Modified: 29 Jul 2024 13:57
URI: https://real.mtak.hu/id/eprint/201065

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