Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties

Nilsson, Jessica and Shteinman, Albert and Degerman, Eva and Enyedy, Éva Anna and Kiss, Tamás and Behrens, Ulrich and Rehder, Dieter and Nordlander, Ebbe (2011) Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties. JOURNAL OF INORGANIC BIOCHEMISTRY, 105 (12). pp. 1795-1800. ISSN 0162-0134

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Abstract

Reaction of N-(2-hydroxybenzyl)-N-(2-picolyl) glycine (H2papy) with VOSO4 in water gives the oxidovanadium(V) oxido-bridged dimer [{(papy)(VO)}2 μ-O)] (1). Similarly, reaction of N-(2-hydroxybenzyl) glycine (H2glysal) with VOSO4 gives [(glysal)VO(H2O)] (2) and reaction of salicylamide (Hsalam) with VOSO4 in methanol gives [(salam)2VO] (3). The crystal structure of the oxido-bridged complex 1 is reported. The insulin-mimetic activity of all three complexes was evaluated with respect to their ability to phosphorylate protein kinase B (PKB). The speciations of complexes 1 and 2 were studied over the pH range 2–10. Complex 1 shows greater stability over the whole pH range but only 2 and 3 exhibit an insulin-mimetic effect.

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