Interaction between iron(II) and hydroxamic acids: oxidation of iron(II) to iron(III) by desferrioxamine B under anaerobic conditions

Farkas, Etelka and Enyedy, Éva Anna and Zékány, László Pál and Deák, György (2001) Interaction between iron(II) and hydroxamic acids: oxidation of iron(II) to iron(III) by desferrioxamine B under anaerobic conditions. JOURNAL OF INORGANIC BIOCHEMISTRY, 83 (2-3). pp. 107-114. ISSN 0162-0134

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Abstract

Interaction between iron(II) and acetohydroxamic acid (Aha), a-alaninehydroxamic acid (a-Alaha), b-alaninehydroxamic acid (b-Alaha), hexanedioic acid bis(3-hydroxycarbamoyl-methyl)amide (Dha) or desferrioxamine B (DFB) under anaerobic conditions was studied by pH-metric and UV–Visible spectrophotometric methods. The stability constants of complexes formed with Aha, a-Alaha, b-Alaha and Dha were calculated and turned out to be much lower than those of the corresponding iron(III) complexes. Stability constants of the iron(II)–hydroxamate complexes are compared with those of other divalent 3d-block metal ions and the Irving–Williams series of stabilities was found to be observed. Above pH 4, in the reactions between iron(II) and desferrioxamine B, the oxidation of the metal ion to iron(III) by the ligand was found. The overall reaction that resulted in the formation of the tris–hydroxamato complex 1 [Fe(HDFB)] and monoamide derivative of DFB at pH 6 is: 21 1 1 1 1 2Fe 13H DFB 52[Fe(HDFB)] 1H DFB–monoamide 1H O14H 4 3 2 Based on these results, the conclusion is that desferrioxamine B can uptake iron in iron(III) form under anaerobic conditions.

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