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Oral administration of a zinc complex improves type 2 diabetes and metabolic syndromes

Adachi, Y. and Yoshida, J. and Kodera, Y. and Kiss, Tamás and Jakusch, Tamás and Enyedy, Éva Anna and Yoshikawa, Y. and Sakurai, H. (2006) Oral administration of a zinc complex improves type 2 diabetes and metabolic syndromes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 351 (1). pp. 165-170. ISSN 0006-291X

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Abstract

Previously, we reported that intraperitoneal injections of the Zn(II) complex (Zn(alx)2) with allixin, which is isolated from dry garlic, with a Zn(O4) coordination environment, exhibited high anti-diabetic effects in obesity-linked type 2 diabetic KKAy mice. However, this complex exhibited low activity when administered orally. To improve the effect of Zn(alx)2, we prepared a novel Zn(II) complex with the allixin-derivative bis(1,6-dimethyl-3-hydroxy-5-methoxy-2-pentyl-1,4-dihydropyridine-4- thionato)Zn(II), abbreviated as Zn(II)–thioallixin-N-methyl (Zn(tanm)2), having a Zn(S2O2) coordination environment; this complex has extremely high in vitro insulin-like activity. Because Zn was extensively absorbed from the gastrointestinal tract when Zn(tanm)2 was orally administered, its anti-diabetic effects were examined in KKAy mice. Daily oral administrations of Zn(tanm)2 for 4 weeks in KKAy mice significantly improved hyperglycemia, glucose intolerance, insulin resistance, hyperleptinemia, obesity, and hypertension. Interestingly, Zn(tanm)2 increased depressed plasma adiponectin levels in the mice. Here, we propose that Zn(tanm)2 will be an orally active therapeutic for obesity-linked type 2 diabetes and metabolic syndromes.

Item Type: Article
Uncontrolled Keywords: Zn(II) complex; Obesity-linked type 2 diabetes; Metabolic syndromes; Adiponectin; Leptin resistance; Insulin resistance; Hypertension
Subjects: Q Science / természettudomány > QD Chemistry / kémia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 31 Jul 2024 02:25
Last Modified: 31 Jul 2024 02:25
URI: https://real.mtak.hu/id/eprint/201085

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