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Phytochemical Investigation of Carex praecox Schreb. and ACE-Inhibitory Activity of Oligomer Stilbenes of the Plant

Dávid, Csilla Zsuzsanna and Kúsz, Norbert and Agbadua, Orinamhe Godwin and Berkecz, Róbert and Kincses, Annamária and Spengler, Gabriella and Hunyadi, Attila and Hohmann, Judit and Vasas, Andrea (2024) Phytochemical Investigation of Carex praecox Schreb. and ACE-Inhibitory Activity of Oligomer Stilbenes of the Plant. MOLECULES, 29 (14). No.-3427. ISSN 1420-3049

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Abstract

Phenolic compounds are the main special metabolites of Cyperaceae species from phytochemical, pharmacological, and chemotaxonomical points of view. The present study focused on the isolation, structure determination, and pharmacological investigation of constituents from Carex praecox. Twenty-six compounds, including lignans, stilbenes, flavonoids, megastigmanes, chromenes, and phenylpropanoids, were identified from the methanol extract of the plant. Five of these compounds, namely, carexines A–E, are previously undescribed natural products. All compounds were isolated for the first time from C. praecox. The ACE-inhibitory activity of seven stilbenoid compounds was tested, and (–)-hopeaphenol proved to be the most active (IC50 7.7 ± 0.9 μM). The enzyme–kinetic studies revealed a mixed-type inhibition; therefore, domain-specific studies were also conducted. The in silico docking of (–)-hopeaphenol to the ACE affirmed some favorable interactions. In addition, the antiproliferative and antibacterial effects of some compounds were also evaluated.

Item Type: Article
Uncontrolled Keywords: Cyperaceae; Carex praecox; lignans; stilbenes; flavonoids; ACE-inhibitory activity
Subjects: R Medicine / orvostudomány > RS Pharmacy and materia medica / gyógyszerészet, gyógyászati eszközök
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 03 Aug 2024 08:19
Last Modified: 03 Aug 2024 08:19
URI: https://real.mtak.hu/id/eprint/201556

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