Effect of surgical mask and N95 respirator mask use on cerebrovascular reactivity

Yaman, Kula Aslı and Meşe, Sultan and Güzel, Vildan and Yabaci, Tak Ayşegül and Yiğit, Mehmet and Balsak, Serdar and Asil Talip, Talip (2024) Effect of surgical mask and N95 respirator mask use on cerebrovascular reactivity. IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE, 77 (7-8). pp. 263-271. ISSN 0019-1442

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Abstract

Background and purpose – Face masks are crucial parts of personal protective equipment (PPE) to reduce the risk of respiratory infections. The COVID-19 outbreak has increased healthcare workers’ use of face masks. This study aimed to evaluate changes in cerebrovascular response among healthcare workers using surgical and N95 respirator masks. Methods – 90 healthcare workers: 30 wearing surgical masks, 30 wearing N95 respirators, and 30 without masks were included. After two-hour of face mask use, the baseline mean flow velocity (MFV) and the mean breath-holding index (BHI) of the bilateral middle cerebral arteries (MCAs) were evaluated with transcranial Doppler ultrasound. The presence of de-novo headache was recorded. BHI values below 0.69 were evaluated as a sign of impaired cerebrovascular reactivity (CVR). Results – The rate of de-novo headache was significantly higher in the N95 respirator mask group (p = 0.004). Compared to the control and surgical mask groups, the N95 respirator mask group had significantly lower values of the baseline MFV of the right MCA (p = 0.003 and p = 0.021, respectively) and mean BHI (p = 0.003 and p = 0.012, respectively). Still, only one N95 respirator mask user had a mean BHI value below 0.69. Conclusion – Surgical masks did not significantly affect cerebral hemodynamics. Although N95 respirator mask use significantly decreased BHI values, the CVR is still within normal limits, and the development of de-novo headache is not directly associated with low CVR.

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