The effect of histamine on body temperature in normal and histamine pre-treated guinea pigs, and the mechanism of the changes

Beznák, Aladár and Kovách, Arisztid and Gáspár-Rády, Zsuzsanna (1948) The effect of histamine on body temperature in normal and histamine pre-treated guinea pigs, and the mechanism of the changes. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 18. pp. 336-352. ISSN 0365-3005

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Abstract

1. ) Recording of the rectal temperature in normal guinea pigs after s. c. and i. p. H injections showed that two kinds of reactions exist: a monophasic gradual fall, and a hipliasic reaction, i. e., an initial rise followed by a fall. 2. ) In animals treated with increasing small doses of H for some weeks a third type of reaction, the inverse, is very frequently observed. In HT animals the total maximum temperature loss is smaller than in the non-treated ones. 3. ) Recording of the temperature in the right and left half of the heart, in the rectum, on the skin of the chest and of the abdomen during H shock showed that there is a decrease in the heat production, besides this a great slowing of the blood-flow through the rectum and a smaller one through the skin. The same results are obtained if the animal is strangulated, except that the fall in the skin temperature is somewhat less. 4. ) The temperature of the heart, rectum and skin slowly decreases in the guinea pig tied supine in a cotton-wool covering. This slow drop is enhanced if the air breathed contains less O₂, decreases if it contains more. 5. ) It is suggested, in agreement with Miss Colldahl, that the temperature changes in H shock are to a large extent due to changes in the O₂ supply to the blood in the lungs. Small broncho-constriction, with consequential compensatory increase of the ventilation, increases O₂ supply and body temperature; a large one, through diminution of the O₂ supply, decreases body temperature. The possibility of the involvement of the heat-regulating centre can almost certainly be excluded. 6. ) Since it was shown in our previous paper that in HT animals under the influence of the same H dose better oxygenation takes place than in the normal, it is suggested that this in its turn is the cause of the smaller diminution of the rectal temperature. The inverse reaction seen in these animals is suggested to be due to this decreased broncho-constriction combined with a secondary compensatory hyperventilation.

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