Method of producing heart hypertrophy in albino rats by narrowing the aorta ascendens

Hajdu, István and Beznák, Margit (1947) Method of producing heart hypertrophy in albino rats by narrowing the aorta ascendens. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 17. pp. 213-220. ISSN 0365-3005

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Abstract

1. ) We publish a new method by which we can produce hypertrophy of the heart by artificial narrowing of the ascending aorta. 2. ) 60% of the animals treated in that way (95 cases altogether) die within the first week in aortic rupture; 20% die in the course of the 2nd week in circulatory decompensation; 20% live on in a compensated state. 3. ) Out of the total hypertrophy thus developed, 80% is that of the left ventricle, 20% that of the atria. The right ventricle hypertrophizes only in decompensation. 4. ) The dry weight (in %) and the ash content (pro) 0,° increases during the first days of the hypertrophy; later on they both regain the normal level.

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