The distribution of lethal sensitivity to histamine in normal and histamine pre-treated guinea pigs

Beznák, Aladár and Gáspár-Rády, Zsuzsanna and Kovách, Arisztid (1947) The distribution of lethal sensitivity to histamine in normal and histamine pre-treated guinea pigs. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 17. pp. 262-277. ISSN 0365-3005

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Abstract

1. In normal guinea pigs of both sexes and in those which underwent a pretreatment of repeated injections with small doses of histamine (HT animals), the ’’characteristic curve” for s. c. histamine injections was determined. 2. The) ALD for H in normal female guinea pigs is 150 µg, 100 g. b. w. µALD = ± 6, same for normal males 250 µg/100 g. b. w. µALD = ± 9. The female guinea pig is 66% more sensitive to this drug than the male. 3. The „characteristic curve” of HT guinea pigs loses its normal shape and assumes a very pronounced positive skewness. Part of the animals therefore develop an increased resistance in consequence of the HT while the sensitivity of another part of the animals remains unaltered. 4. Experimental evidence is presented proving, in the HT animals, the oscillatory nature of the resistance of one and the same guinea pig towards H. It is suggested- that the characteristic curve is formed rather by the regular coincidence of certain sensitivities oscillating within limits than by distribution of animals with standard but individually varying sensitivity. 5. Whether HT is carried) out with doses considerably below the MLD for a medium time (3 weeks) or with doses rapidly (in one week) reaching the lethal dose range does not seem to alter the result of the HT. The maintenance of H shocks with 40% LD for a long time neither increases nor diminishes the acquired resistance of the animals. 6. The authors emphasize that the results of their experiments are not to be used as arguments in favour of the existence of histamine desensitization in man against surgical shock.

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