Unveiling the Hungarian landscape of laboratory and clinical management capacities for invasive fungal infections : navigating the frontlines against fungal menaces

Kovács, Renátó and Majoros, László and Stemler, Jannik and Cornely, Oliver Andreas and Salmanton-García, Jon (2023) Unveiling the Hungarian landscape of laboratory and clinical management capacities for invasive fungal infections : navigating the frontlines against fungal menaces. THERAPEUTIC ADVANCES IN INFECTIOUS DISEASE, 10. pp. 1-11. ISSN 2049-9361

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Abstract

Background: Antifungal diagnostic capacity has been documented in various countries, there is a lack of comprehensive research on clinical mycology diagnostics and treatment in Hungary. Methods: We conducted an online survey encompassing questions that explored various aspects of the mycology diagnostic and antifungal therapy-related information. The survey aimed to gather details about institutional profiles, perceptions of invasive fungal infections (IFIs), and access to microscopy, culture, serology, antigen detection, molecular testing, and therapeutic drug monitoring. Results: As of May 2023, a total of 17 institutions responded to the questionnaire. Seven participants categorized the institutional incidence of IFI as ‘very low’, four as ‘low’, and six as ‘mild’. The majority of centers identified Candida spp. (94%) and Aspergillus spp. (82%) as the most prevalent fungal pathogens. Nearly half of the laboratories (47%) reported using matrixassisted laser desorption/ionization-time of flight mass spectrometry for identification. All institutions had access to microscopy and culture-based diagnostic approaches. A significant number of centers had access to antigen detection (71%) and various molecular assays (59%). Regarding antifungal agents, all reporting sites used at least one triazole, with voriconazole (77%) being the most common mold-active azole. Furthermore, 71% of the centers applied at least one formulation of amphotericin B, and 65% to one echinocandin. However, only 18% of the centers used 5-flucytosine. Conclusion: Resource availability for diagnosing and treating IFI in Hungary varies across hospitals based on location. Surveys help identify gaps and limitations in this area. To address these challenges, interregional cooperation within Hungary could be a facilitating strategy.

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