Borbély, Éva and Pethő, Gábor (2024) Drug effects on neuropeptides and their receptors : Big hopes but moderate success in the treatment of chronic pain. CURRENT OPINION IN PHARMACOLOGY, 77. No. 102474. ISSN 1471-4892
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Abstract
Neuropeptides, including tachykinins, CGRP, and somatostatin, are localized in a peptidergic subgroup of nociceptive primary afferent neurons. Tachykinins and CGRP are pronociceptive, somatostatin is an antinociceptive mediator. Intensive drug research has been performed to develop tachykinin and CGRP antagonists, and somatostatin agonists as analgesics. CGRP receptor antagonists are efficacious and welltolerated drugs in migraine. Monoclonal antibodies against CGRP or its receptor are used for the prophylactic treatment of migraine. Tachykinin NK1 receptor antagonists failed as analgesics but are used for chemotherapy-induced nausea and vomiting. New, orally active somatostatin 4 receptor agonists are promising drug candidates for treating various pain conditions.
Item Type: | Article |
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Additional Information: | Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti Str. 12, Pécs, H-7624, Hungary Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Rókus Str. 2, Pécs, H-7624, Hungary Centre for Neuroscience, University of Pécs, Ifjúság Str. 6, Pécs, H-7624, Hungary Export Date: 13 August 2024 CODEN: COPUB Correspondence Address: Borbély, É.; Department of Pharmacology and Pharmacotherapy, Szigeti Str. 12, Hungary; email: eva.borbely@aok.pte.hu |
Subjects: | R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában |
SWORD Depositor: | MTMT SWORD |
Depositing User: | MTMT SWORD |
Date Deposited: | 05 Sep 2024 11:07 |
Last Modified: | 05 Sep 2024 11:07 |
URI: | https://real.mtak.hu/id/eprint/204350 |
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