Novák, Tibor Tamás and Aradi, Klára and Gömöry, Ágnes and Nonn, Melinda and Hornyánszky, Gábor and Kiss, Loránd (2024) Studies on fluorofunctionalization of some functionalized alkene scaffolds. RESULTS IN CHEMISTRY, 7. No. 101309. ISSN 2211-7156
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Abstract
A study on some halofluorination and fluoroselenation protocols of various functionalized cyclic olefins, such as esters, lactams or amino esters as model compounds is presented. The ring olefin bond functionalizations were based on their activation either with NBS, NIS or PhSeBr followed by treatment with nucleophilic fluorinating agents, such as Deoxo-Fluor. The attempted synthetic assays have been found to be highly substrate dependent, influenced by the nature of the functional groups present on the cycloalkene skeleton as well as the stereostructural architecture of the starting model compounds.
| Item Type: | Article |
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| Additional Information: | Institute of Organic Chemistry, Stereochemistry Research Group, HUN-REN Research Centre for Natural Sciences, 1117 Budapest, Magyar tudósok krt. 2, Hungary Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111, Budapest, Hungary Institute of Organic Chemistry, MS Proteomics Research Group, HUN-REN Research Centre for Natural Sciences, Magyar tudósok krt. 2, Budapest, 1117, Hungary MTA TTK Lendület Artificial Transporter Research Group, Institute of Materials and Environmental Chemistry, HUN-REN Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok krt. 2, Budapest, 1117, Hungary Export Date: 24 January 2024 Correspondence Address: Kiss, L.; Institute of Organic Chemistry, 1117 Budapest, Magyar tudósok krt. 2, Hungary; email: kiss.lorand00@gmail.com Funding details: European Commission, EC Funding details: Hungarian Scientific Research Fund, OTKA, RRF-2.3.1-21-2022-00015 Funding details: Magyar Tudományos Akadémia, MTA Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFI, / OTKA FK 145394, K 142266 Funding text 1: The authors gratefully acknowledge financial support from the National Research, Development and Innovation Office of Hungary (NKFIH/OTKA FK 145394 and K 142266). Project no. RRF-2.3.1-21-2022-00015 has been implemented with the support provided by the European Union. This work was supported by the János Bolyai Research Scholarship to M.N. of the Hungarian Academy of Sciences. Funding text 2: The authors gratefully acknowledge financial support from the National Research, Development and Innovation Office of Hungary ( NKFIH / OTKA FK 145394 and K 142266 ). Funding text 3: Project no. RRF-2.3.1-21-2022-00015 has been implemented with the support provided by the European Union . This work was supported by the János Bolyai Research Scholarship to M.N. of the Hungarian Academy of Sciences . |
| Uncontrolled Keywords: | Cycloalkenes, Fluorination, Olefin difunctionalization, Regiochemistry, Stereochemistry |
| Subjects: | Q Science / természettudomány > QD Chemistry / kémia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 09 Sep 2024 08:37 |
| Last Modified: | 09 Sep 2024 08:37 |
| URI: | https://real.mtak.hu/id/eprint/204542 |
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