Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies

Megyesfalvi, Zsolt and Heeke, Simon and Drapkin, Benjamin J. and Solta, Anna and Kovacs, Ildiko and Boettiger, Kristiina and Horvath, Lilla and Ernhofer, Busra and Fillinger, Janos and Renyi-Vamos, Ferenc and Aigner, Clemens and Schelch, Karin and Lang, Christian and Marko-Varga, Gyorgy and Gay, Carl M. and Byers, Lauren A. and Morris, Benjamin B. and Heymach, John V. and Van Loo, Peter and Hirsch, Fred R. and Dome, Balazs (2023) Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies. CANCER CELL, 41 (9). pp. 1535-1540. ISSN 1535-6108

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Abstract

The understanding of small cell lung cancer (SCLC) biology has increased dramatically in recent years, but the processes that allow SCLC to progress rapidly remain poorly understood. Here, we advocate the integration of rapid autopsies and preclinical models into SCLC research as a comprehensive strategy with the potential to revolutionize current treatment paradigms.

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