Gut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients

Marfil-Sánchez, Andrea and Seelbinder, Bastian and Ni, Yueqiong and Varga, Janos and Berta, Judit and Hollosi, Virag and Dome, Balazs and Megyesfalvi, Zsolt and Dulka, Edit and Galffy, Gabriella and Weiss, Glen J. and Panagiotou, Gianni and Lohinai, Zoltan (2021) Gut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients. PLOS ONE, 16 (11). No.-e0259898. ISSN 1932-6203

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Abstract

Impaired exercise tolerance and lung function is a marker for increased mortality in lung cancer patients undergoing lung resection surgery. Recent data suggest that the gut-lung axis regulates systemic metabolic and immune functions, and microbiota might alter exercise tolerance. Here, we aimed to evaluate the associations between gut microbiota and outcomes in lung cancer patients who underwent lung resection surgery. We analysed stool samples, from 15 early-stage lung cancer patients, collected before and after surgical resection using shotgun metagenomic and Internal Transcribed Spacer (ITS) sequencing. We analysed microbiome and mycobiome associations with post-surgery lung function and cardiopulmonary exercise testing (CPET) to assess the maximum level of work achieved. There was a significant difference, between pre- and post-surgical resection samples, in microbial community functional profiles and several species from Alistipes and Bacteroides genus, associated with the production of SCFAs, increased significantly in abundance. Interestingly, an increase in VO2 coincides with an increase in certain species and the "GABA shunt" pathway, suggesting that treatment outcome might improve by enriching butyrate-producing species. Here, we revealed associations between specific gut bacteria, fungi, and their metabolic pathways with the recovery of lung function and exercise capacity.

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