Synthesis of New Tetracyclic Ring Systems: Bridged Derivatives of Hydroxy-, Sulfanyl- and Amino-Substituted Dibenzo[c,f][1,2]Thiazepine S,S-Dioxides

Berecz, Gábor and Szabó, Dávid and Dancsó, András and Lauritz, Mária and Simig, Gyula and Kiss, Loránd and Volk, Balázs (2024) Synthesis of New Tetracyclic Ring Systems: Bridged Derivatives of Hydroxy-, Sulfanyl- and Amino-Substituted Dibenzo[c,f][1,2]Thiazepine S,S-Dioxides. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. No.-e202400835. ISSN 1434-193X

Text Eur J Org Chem - 2024 - Berecz - Synthesis of New Tetracyclic Ring Systems Bridged Derivatives of Hydroxy‐ Sulfanyl‐ and.pdf - Published Version Restricted to Repository staff only Download (2MB)

Abstract

In continuation of our commitment to the synthesis of new ring systems based on the 6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide core of the antidepressant drug tianeptine, we have incorporated two- and/or three-carbon bridges between the nitrogen atom of the sulfonamide moiety and the N-, O- or S-substituent at position 11 of the tricycle. The synthesis of 5 new ring systems is described and demonstrated with several target compounds.

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