Gulyás, Dominik and Kovács, Gábor and Jankovics, István and Hidvégi, Máté and Dénes, Béla and Kálfalvy-Molnár, Lilla and Nagypál, Rebeka and Lőrincz, Márta (2024) Antimetastatic effect of intratumoral Treg antagonists in mice with renal cancer. ACTA VETERINARIA HUNGARICA, 72 (2). pp. 109-115. ISSN 0236-6290
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Abstract
The interplay of regulatory T cells (Tregs) within the tumour microenvironment presents a significant challenge in anticancer immunotherapy. This study investigates the potential of Treg blockade to enhance the efficiency of effector T cells. Two distinct treatment cocktails were examined: 3p-hpRNA (5′ triphosphate hairpin RNA) combined with unmethylated CpG oligonucleotide (CpG); CpG in combination with OX40 receptor-specific monoclonal antibody (anti-OX40). Treatment efficacy was assessed using a murine model of kidney adenocarcinoma.
| Item Type: | Article |
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| Uncontrolled Keywords: | immunotherapy, cancer therapy, companion animal, regulatory T cell, adjuvant, monoclonal antibody |
| Subjects: | S Agriculture / mezőgazdaság > SV Veterinary science / állatorvostudomány |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 18 Nov 2024 11:55 |
| Last Modified: | 18 Nov 2024 11:55 |
| URI: | https://real.mtak.hu/id/eprint/209895 |
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