Petri, Gábor and Pórszász, J. and Pórszász-Gibiszer, K. (1971) The action of sympatholytic drugs in experimental intestinal paralysis. ACTA CHIRURGICA ACADEMIAE SCIENTIARUM HUNGARICAE, 12 (4). pp. 391-403. ISSN 0001-5431
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Abstract
A total of 106 out of 129 cats anaesthetized with hexobarbital exhibited no intestinal movements after laparotomy. This state served as a model of postoper ative intestinal paralysis. Twenty autonomic drugs of different mode and site of action have been tested on this model for their capacity to restore peristalsis. Chlorpromazine and trifluperidol were found particularly effective in clinical ex perience; their effect is ascribed to their alpha-blocking property, which relieves the peristaltic reflex from inhibition by catecholamines. Postoperative intestinal paralysis is attributed to an autonomic imbalance due to sympathetic dominance.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 09 Dec 2024 10:07 |
| Last Modified: | 09 Dec 2024 10:07 |
| URI: | https://real.mtak.hu/id/eprint/211203 |
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