Bálint, Erika and Kallai, M. and Kovacs, O. and Bolcskei, H. and Keglevich, György (2014) O-Arylation of Iodophenols with 2-Fluorobenzaldehyde Under Microwave Conditions. LETTERS IN DRUG DESIGN AND DISCOVERY, 11 (1). pp. 114-120. ISSN 1570-1808
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Abstract
The arylation of 4-iodo-, 2-iodo- and 3-iodophenols with 2-fluorobenzaldehyde may be carried out in the presence of K2CO3 in DMF as the solvent under microwave conditions. The arylation of 4-iodophenole was promoted by the use of triethylbenzylammonium chloride (TEBAC) as the phase transfer catalyst. In the other model reactions, the use of TEBAC was harmful. By-products formed by isomerization and disproportionation were also detected.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARYL; PHENOLS; ESTERIFICATION; ETHERS; IRRADIATION; C-ALKYLATION; ACTIVE METHYLENE; SOLVENT-FREE CONDITIONS; PHASE-TRANSFER CATALYSIS; phase transfer catalysis; microwave; arylation; Iodophenols; 2-Flourobenzaldehyde |
| Subjects: | Q Science / természettudomány > QD Chemistry / kémia > QD04 Organic chemistry / szerves kémia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 05 Feb 2015 14:44 |
| Last Modified: | 31 Dec 2015 00:15 |
| URI: | http://real.mtak.hu/id/eprint/21284 |
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