Targeted Copper Radioisotopes for Nuclear Medicine : Production of 64Cu from natNi by Cyclotron and 67Cu by Reactor

Szűcs, Zoltán and Dóczi, Rita (2014) Targeted Copper Radioisotopes for Nuclear Medicine : Production of 64Cu from natNi by Cyclotron and 67Cu by Reactor. In: International Conference on Application of Radiotracers and Energetic Beams in Sciences. ARCEBS 14, 12-18. January 2014, Kolkata, India.

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Abstract

The Copper is one of the most important trace elements in the biosphere. Its importance in blood system and chelate bonds to the bioactive macro-peptides are well known. The nuclear medical applications of Copper radioisotopes such as 64Cu also have wide literature. The 67Cu became the target of the scientific interest due to the optimal nuclear properties for nuclear medicine. The optimal production of these isotopes in quality of high specific activity is different. For production of 64Cu it is more preferable to apply the 64Ni(p,n)64Cu nuclear reaction by cyclotron. The production of 67Cu is possible using the 67Zn(n,p)67Cu nuclear reaction by nuclear reactor. Theoretically the 64Ni(,p)67Cu and 64Ni(7Li,)67Cu are also useable to produce the 67Cu, but the Atomki’s cyclotron isn’t dedicated for that reactions. However for that two radioisotopes have two different production routes, both radioisotopes can be separated by the same chemical method. The strength of complexation of metal ions with chloride ions depends of the concentration of chloride ion. This is the theoretical background for separation of different transition metal ions by ion-chromatography [3]

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