TRP channels and pruritus

Tóth, Balázs István and Bíró, Tamás (2013) TRP channels and pruritus. OPEN PAIN JOURNAL, 6 (SPEC.I). pp. 62-80. ISSN 1876-3863

Text
OpenPainJ_6_62.pdf
Restricted to Repository staff only
Download (291kB) | Request a copy

Abstract

Itch (pruritus) is one of the most often seen sensory phenomena in clinical practice. Recent neurophysiological findings proposed the existence of a novel pruriceptive system which includes a multitude of pruritogenic (itch-inducing) peripheral mediators, itch-selective pruriceptors, sensory afferent networks, spinal cord neurons, and certain central nervous system regions. In this review, we first introduce major features of the pruriceptive system. We then focus on defining the roles of transient receptor potential (TRP) ion channels in skin-coupled itch and provide compelling evidence that certain thermosensitive TRP channels (especially TRPV1, TRPV3, TRPV4, and TRPA1) are indeed key players in pruritus pathogenesis. Finally, we propose TRP-centered future experimental directions towards the therapeutic targeting of TRP channels in the clinical management of itch. © Tóth and Bíró; Licensee Bentham Open.

Item Type:	Article
Uncontrolled Keywords:	trpv3 gene; synaptic transmission; sensory nerve; review; psychogenic itch; psoriasis; pruriceptive itch; protein protein interaction; protein localization; PROTEIN FUNCTION; protein expression; protein analysis; priority journal; notalgia paresthetica; nonhuman; neurophysiology; NEUROPATHOLOGY; neuropathic itch; neurogenic itch; neurodermatitis; neuralgia; Keratinocyte; Inflammation; immunostimulation; IMMUNOLOGICAL SYNAPSE; human; heat sensitivity; GENE; gain of function mutation; Drug targeting; drug potency; disease classification; cytokine release; Cholestasis; channel gating; Cell Differentiation; burning sensation; Atopic dermatitis; anus pruritus; allergic rhinitis; vanilloid receptor agonist; vanilloid receptor 4 agonist; vanilloid receptor 4; vanilloid receptor 3; vanilloid receptor 1 antagonist; vanilloid receptor 1; unindexed drug; unclassified drug; transient receptor potential channel M8; transient receptor potential channel A1; transient receptor potential channel; toll like receptor 2; skf96365; RESINIFERATOXIN; pruritogen derivative; proteinase; PROSTAGLANDIN; PACLITAXEL; pac 14028; neurotrophin; NEUROPEPTIDE; monocyte chemotactic protein 1; leukotriene B4; interleukin 8; interleukin 4; interleukin 31; interleukin 13; HISTAMINE; CAPSAZEPINE; CAPSAICIN; biological factor; 1 [2 (4 methoxyphenyl) 2 [3 (4 methoxyphenyl)propoxy]ethyl] 1h imidazole; TRP CHANNELS; Thermosensitive; pruritus; Pruritogenic
Subjects:	Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3015 Molecular biology / molekuláris biológia R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
SWORD Depositor:	MTMT SWORD
Depositing User:	MTMT SWORD
Date Deposited:	13 Feb 2015 15:12
Last Modified:	13 Feb 2015 15:12
URI:	http://real.mtak.hu/id/eprint/21742

Actions (login required)

Edit Item