Koncz, Balázs and Balogh, Gergő Mihály and Manczinger, Máté (2024) A journey to your self: The vague definition of immune self and its practical implications. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 121 (23). No. e2309674121. ISSN 0027-8424
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Abstract
The identification of immunogenic peptides has become essential in an increasing number of fields in immunology, ranging from tumor immunotherapy to vaccine development. The nature of the adaptive immune response is shaped by the similarity between foreign and self-protein sequences, a concept extensively applied in numerous studies. Can we precisely define the degree of similarity to self? Furthermore, do we accurately define immune self? In the current work, we aim to unravel the conceptual and mechanistic vagueness hindering the assessment of self-similarity. Accordingly, we demonstrate the remarkably low consistency among commonly employed measures and highlight potential avenues for future research.
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| Additional Information: | Funding Agency and Grant Number: Horizon Europe research and innovation programme [101136582 Acronym ID-DarkMatter-NCD] Funding text: The work was supported by the European Union's Horizon 2020 research and innovation program grant No. 739593 (B.K., G.M.B., and M.M.) .This work was supported by Hungarian Scientific Research Fund grant FK-142312 (M.M.) and PD-146654 (B.K.) . M.M. and B.K. were supported by the Bolyai Janos Research Fellowship of the Hungarian Academy of Sciences. M.M. and B.K. were supported by the & Uacute;NKP-23-5, and G.M.B. was supported by the & Uacute;NKP-22-4 and & Uacute;NKP-23-4 New National Excellence Program of the Ministry Culture and Innovation from the source of the National Research, Development and Innovation Fund. This project has received funding from the European Union's Horizon Europe research and innovation programme under grant agreement No 101136582 Acronym ID-DarkMatter-NCD. Figs. 1 A and B and 2 were created with https://BioRender.com .r & Uacute;NKP-22-4 and & Uacute;NKP-23-4 New National Excellence Program of the Ministry Culture and Innovation from the source of the National Research, Development and Innovation Fund.This project has received funding from the European Union'sr Horizon Europe research and innovation programme under grant agreement No 101136582 Acronym ID-DarkMatter-NCD. Figs. 1 A and B and 2 were created with https://BioRender.com . |
| Uncontrolled Keywords: | immunogenicity | neoantigen | T cell repertoire | immune self | infectious diseases |
| Subjects: | Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 14 Apr 2025 08:43 |
| Last Modified: | 14 Apr 2025 08:43 |
| URI: | https://real.mtak.hu/id/eprint/217745 |
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