Vályi, Péter and Wirth, Roland and Minárovits, János and Strang, Orsolya and Maróti, Gergely and Kovács, Kornél Lajos (2024) The oral microbiome of a family including Papillon-Lefèvre-syndrome patients and clinically healthy members. BMC ORAL HEALTH, 24. No. 158. ISSN 1472-6831
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Abstract
Aims: The oral microbiota composition of patients diagnosed with Papillon-Lefèvre-syndrome and treated for several years were compared to those existing in the oral cavity of the clinically healthy family members and a cohort of patients having various stages of chronic periodontitis. Materials and methods: A family with two sisters afected with severe periodontitis and with the typical skin symptoms of Papillon-Lefèvre-syndrome, and symptomless parents and third sibling were investigated. The Patients received periodontal treatment for several years and their oral microbiome was analysed by amplicon sequencing. Data were evaluated by microbial cluster analysis. Results: The microbiome of the patients with Papillon-Lefèvre-syndrome was predominated with Aggregatibacter actinomycetemcomitans and associated oral periodontopathogens. Although the clinically healthy family members showed no oral disorder, their microbiome resembled that of subjects having mild periodontitis. Conclusions: Predominance of A. actinomycetemcomitans in the subgingival microbiome of patients with PapillonLefèvre-syndrome suggests that specifc treatment strategies directed against this pathobiont may improve the oral health status of the afected individuals.
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| Additional Information: | Department of Oral Diagnostics, Faculty of Dentistry, Semmelweis University, Szentkirályi u 47, Budapest, H1085, Hungary Department of Biotechnology, University of Szeged, Közép fasor 52, Szeged, H6726, Hungary Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza L. krt 64, Szeged, H6720, Hungary Institute of Biophysics, Biological Research Center, Temesvári krt 62, Szeged, H6726, Hungary Institute of Plant Biology, Biological Research Center, Temesvári krt 62, Szeged, H6726, Hungary Export Date: 1 May 2024 Correspondence Address: Vályi, P.; Department of Oral Diagnostics, Szentkirályi u 47, Hungary; email: valyi.peter@dent.semmelweis-univ.hu Chemicals/CAS: dipeptidyl peptidase I, 9032-68-2 Funding details: European Regional Development Fund, ERDF, FK123899, GINOP-2.3.2-15-2016-00011, PD132145 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFI Funding text 1: This work was supported by the European Regional Development Fund to a project led by JM; grant No.: GINOP-2.3.2-15-2016-00011. RW (PD132145) and GM (FK123899) received support from the National Research, Development and Innovation Office (NKFIH), Hungary. Funding text 2: Open access funding provided by Semmelweis University. This work was supported by the European Regional Development Fund to a project led by JM; grant No.: GINOP-2.3.2-15-2016-00011. RW (PD132145) and GM (FK123899) received support from the National Research, Development and Innovation Office (NKFIH), Hungary. |
| Uncontrolled Keywords: | Papillon-Lefèvre-syndrome, Periodontitis, Aggregatibacter actinomycetemcomitans, Oral metagenome, Periodontopathogens, Recessive mutation, Cathepsin C |
| Subjects: | R Medicine / orvostudomány > RK Dentistry / fogászat |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 21 Apr 2025 18:27 |
| Last Modified: | 21 Apr 2025 18:27 |
| URI: | https://real.mtak.hu/id/eprint/217955 |
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