Mitochondrial differentiation during Spermatogenesis: Lessons from Drosophila melanogaster

Vedelek, Viktor and Jankovics, Ferenc and Zádori, János and Sinka, Rita (2024) Mitochondrial differentiation during Spermatogenesis: Lessons from Drosophila melanogaster. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (7). No. 3980. ISSN 1661-6596

Preview

Text VedelekV_Mitochondrial.pdf - Published Version Available under License Creative Commons Attribution. Download (7MB) | Preview

Abstract

Numerous diseases can arise as a consequence of mitochondrial malfunction. Hence, there is a significant focus on studying the role of mitochondria in cancer, ageing, neurodegenerative diseases, and the field of developmental biology. Mitochondria could exist as discrete organelles in the cell; however, they have the ability to fuse, resulting in the formation of interconnected reticular structures. The dynamic changes between these forms correlate with mitochondrial function and mitochondrial health, and consequently, there is a significant scientific interest in uncovering the specific molecular constituents that govern these transitions. Moreover, the specialized mitochondria display a wide array of variable morphologies in their cristae formations. These inner mitochondrial structures are closely associated with the specific functions performed by the mitochondria. In multiple cases, the presence of mitochondrial dysfunction has been linked to male sterility, as it has been observed to cause a range of abnormal spermatogenesis and sperm phenotypes in different species. This review aims to elucidate the dynamic alterations and functions of mitochondria in germ cell development during the spermatogenesis of Drosophila melanogaster.

Actions (login required)

Edit Item