Yan, Feng and Alhajeri, Zaid A. and Nyúl-Tóth, Ádám and Wang, Chen and Zhang, Qinghao and Mercyshalinie, Ebenezer Raj Selvaraj and Delfavero, Jordan and Ahire, Chetan and Mutembei, Bornface M. and Tarantini, Stefano and Csiszar, Anna and Tang, Qinggong (2024) Dimension-based quantification of aging-associated cerebral microvasculature determined by optical coherence tomography and two-photon microscopy. JOURNAL OF BIOPHOTONICS, 17 (3). No. :e202300409. ISSN 1864-063X
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Abstract
Cerebral microvascular health is a key biomarker for the study of natural aging and associated neurological diseases. Our aim is to quantify aging‐associated change of microvasculature at diverse dimensions in mice brain. We used optical coherence tomography (OCT) and two‐photon microscopy (TPM) to obtain nonaged and aged C57BL/6J mice cerebral microvascular images in vivo. Our results indicated that artery & vein, arteriole & venule, and capillary from nonaged and aged mice showed significant differences in density, diameter, complexity, perimeter, and tortuosity. OCT angiography and TPM provided the comprehensive quantification for arteriole and venule via compensating the limitation of each modality alone. We further demonstrated that arteriole and venule at specific dimensions exhibited negative correlations in most quantification analyses between nonaged and aged mice, which indicated that TPM and OCT were able to offer complementary vascular information to study the change of cerebral blood vessels in aging.<jats:inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/jbio202300409-gra-0001.png" xlink:title="image" />
| Item Type: | Article |
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| Additional Information: | Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United States Vascular Cognitive Impairment, Neurodegeneration, and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary International Training Program in Geroscience, Institute of Biophysics, Biological Research Centre, Eötvös Loránd Research Network, Szeged, Hungary Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Translational Medicine, Semmelweis University, Budapest, Hungary Institute for Biomedical Engineering, Science, and Technology (IBEST), University of Oklahoma, Norman, OK, United States Cited By :1 Export Date: 9 January 2025 Correspondence Address: Tang, Q.; Stephenson School of Biomedical Engineering, United States; email: qtang@ou.edu Funding details: National Cancer Institute, NCI Funding details: American Cancer Society, ACS Funding details: National Institute of General Medical Sciences, NIGMS, U54GM104938, P20GM103639 Funding details: National Institute of General Medical Sciences, NIGMS Funding details: National Institutes of Health, NIH, R01CA255840, R01DK133717, 5U01HL152410‐04 Funding details: National Institutes of Health, NIH Funding details: Oklahoma Center for the Advancement of Science and Technology, OCAST, P20 GM135009, HR23‐071 Funding details: Oklahoma Center for the Advancement of Science and Technology, OCAST Funding details: University of Oklahoma Health Sciences Center, OUHSC, P30CA225520 Funding details: University of Oklahoma Health Sciences Center, OUHSC Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS100782 Funding details: National Institute of Neurological Disorders and Stroke, NINDS Funding details: University of Oklahoma, OU, IRG‐19‐142‐01 Funding details: University of Oklahoma, OU Funding details: American Heart Association, AHA, AHA834339 Funding details: American Heart Association, AHA Funding details: National Institute on Aging, NIA, R01AG055395, R01AG068295, RF1AG072295, R01AG070915, K01AG073614 Funding details: National Institute on Aging, NIA Funding details: National Science Foundation, NSF, 2238648, OIA‐2132161 Funding details: National Science Foundation, NSF Funding text 1: This work was supported by grants from the University of Oklahoma Health Sciences Center (P30CA225520), Faculty Investment Program from University of Oklahoma, Institutional Research Grant number IRG-19-142-01 from the American Cancer Society, National Science Foundation (OIA-2132161, 2238648), National Institute of Health (R01DK133717, R01CA255840, 5U01HL152410-04), Oklahoma Shared Clinical and Translational Resources (NIGMS U54GM104938), Oklahoma Center for the Advancement of Science and Technology (HR23-071), and the medical imaging COBRE (P20 GM135009). Histology service provided by the Tissue Pathology Shared Resource was supported in part by the National Institute of General Medical Sciences COBRE Grant P20GM103639 and National Cancer Institute Grant P30CA225520 of the National Institutes of Health. American Heart Association (ANT: AHA834339), the Oklahoma Center for the Advancement of Science and Technology, the National Institute on Aging (RF1AG072295, R01AG055395, R01AG068295; R01AG070915, K01AG073614), the National Institute of Neurological Disorders and Stroke (R01NS100782). Financial support was provided by the OU Libraries' Open Access Fund. Funding text 2: This work was supported by grants from the University of Oklahoma Health Sciences Center (P30CA225520), Faculty Investment Program from University of Oklahoma, Institutional Research Grant number IRG\\u201019\\u2010142\\u201001 from the American Cancer Society, National Science Foundation (OIA\\u20102132161, 2238648), National Institute of Health (R01DK133717, R01CA255840, 5U01HL152410\\u201004), Oklahoma Shared Clinical and Translational Resources (NIGMS U54GM104938), Oklahoma Center for the Advancement of Science and Technology (HR23\\u2010071), and the medical imaging COBRE (P20 GM135009). Histology service provided by the Tissue Pathology Shared Resource was supported in part by the National Institute of General Medical Sciences COBRE Grant P20GM103639 and National Cancer Institute Grant P30CA225520 of the National Institutes of Health. American Heart Association (ANT: AHA834339), the Oklahoma Center for the Advancement of Science and Technology, the National Institute on Aging (RF1AG072295, R01AG055395, R01AG068295; R01AG070915, K01AG073614), the National Institute of Neurological Disorders and Stroke (R01NS100782). Financial support was provided by the OU Libraries' Open Access Fund. |
| Uncontrolled Keywords: | cerebral blood vessel, dimension-based quantification, optical coherence tomography, twophoton microscopy |
| Subjects: | Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 21 Apr 2025 18:53 |
| Last Modified: | 21 Apr 2025 18:53 |
| URI: | https://real.mtak.hu/id/eprint/217959 |
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