Is there a connection between postprandial hyperglycemia and IGT related sensory nerve dysfunction?

Németh, Nóra and Putz, Zsuzsanna and Istenes, Ildikó and Körei, Anna Erzsébet and Vági, Orsolya and Kempler, Miklós and Gandhi, R and Jermendy, G and Tesfaye, S and Tabák, Ádám and Kempler, Péter (2017) Is there a connection between postprandial hyperglycemia and IGT related sensory nerve dysfunction? NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 27 (7). pp. 609-614. ISSN 0939-4753

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Abstract

Background and Aims: To assess the risk factors for sensory nerve dysfunction in subjects with isolated impaired glucose tolerance (IGT). Methods and Results: Seventy-two people with isolated IGT (WHO 1999 criteria) and 39 gender and age-matched healthy volunteers underwent detailed clinical and neurological assessment including quantitative sensory testing using the Neurometer device (current perception threshold measurement on four limbs at three different frequencies). Sensory nerve dysfunction was defined as at least two abnormalities on any frequencies on the upper or lower limbs. Sensory nerve dysfunction was more prevalent among subjects with IGT compared to controls (58.3 vs. 10.3%, OR: 11.23, 95%CI: 3.57-35.35). This association was not influenced by BMI, systolic and diastolic blood pressure, heart rate and autonomic neuropathy (multiple adjusted OR: 13.87, 95%CI: 3.18-60.58), but further adjustment for glycaemic measures abolished the association (OR: 1.58, 95%CI: 0.07-35.68). Assessing the components of glycaemic measures separately, the association between sensory nerve dysfunction and IGT was not affected by HbAlc (OR: 13.94, 95%CI: 1.84-105.5). It was, however, substantially attenuated by fasting plasma glucose (OR: 6.75, 95%CI: 1.33-34.27) while the significance was lost after adjustment for 120-min postload glucose level (OR: 3.76, 95%CI: 0.26-54.10). In the pooled population assessed, independent determinants of sensory nerve dysfunction were older age, cardiovascular autonomic neuropathy, 120-min glucose and higher height. Conclusions: Sensory nerve dysfunction amongst subjects with IGT was not explained by cardiovascular covariates, only by glycaemic measures. In addition to 120-min glucose, cardiovascular autonomic neuropathy, age, arid height were the independent determinants of sensory nerve dysfunction.

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