Therapeutic and pharmacological applications of extracellular vesicles and lipoproteins

Németh, Krisztina and Kestecher, Brachyahu Meir and Ghosal, Sayam and Bodnár, Bernadett Réka and Kittel, Ágnes and Hambalkó, Szabolcs and Kovácsházi, Csenger and Giricz, Zoltán and Ferdinandy, Péter and Osteikoetxea, Xabier and Burkhardt, Ralph and Buzás, Edit Irén and Orsó, Evelin Katalin (2024) Therapeutic and pharmacological applications of extracellular vesicles and lipoproteins. BRITISH JOURNAL OF PHARMACOLOGY, 181 (23). pp. 4733-4749. ISSN 0007-1188

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Abstract

In recent years, various approaches have been undertaken to eliminate lipoproteins co‐isolated with extracellular vesicles, as they were initially regarded as contaminating entities. However, novel discoveries are reshaping our perspective. In body fluids, these distinct particles not only co‐exist, but also interactions between them are likely to occur. Extracellular vesicles and lipoproteins can associate with each other, share cargo, influence each other's functions, and jointly have a role in the pathomechanisms of diseases. Additionally, their association carries important implications for therapeutic and pharmacological aspects of lipid‐lowering strategies. Extracellular vesicles and lipoprotein particles may have roles in the elimination of each other from the circulation. The objective of this minireview is to delve into these aspects. Here, we show that under certain physiological and pathological conditions, extracellular vesicles and lipoproteins are ‘partners’ rather than ‘strangers’ or ‘rivals’.

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