Gémes, Nikolett and Rónaszéki, Benedek and Modok, Szabolcs and Borbényi, Zita and Földesi, Imre and Trucza, Éva Gabriella and Godza, Blanka and László, Zsuzsanna and Csernus, Balázs and Krenács, László and Bagdi, Enikő and Szabó, Enikő and Puskás, László and Bertagnolo, Valeria and Szebeni, Gábor (2025) Multiplex immunophenotyping of human acute myeloid leukemia patients revealed single -cell heterogeneity with special attention on therapy sensitive and therapy resistant subpopulations. FRONTIERS IN IMMUNOLOGY, 16. ISSN 1664-3224
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Abstract
Understanding leukemia-associated immunophenotypes (LAIP) could assist in the design of therapies to ameliorate patient benefits in acute myeloid leukemia (AML). In our study, focusing on single-cell heterogeneity in therapeutic resistance, flow cytometric immunophenotyping of the peripheral blood of therapy-naive and follow-up AML patients versus age and sex-matched healthy controls (HCs) was performed.
| Item Type: | Article |
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| Additional Information: | Funding Agency and Grant Number: National Research, Development, and Innovation Office (NKFI), Hungary [2023-1.1.1-PIACI_FOKUSZ-2024-00036, 2020-1.1.6-JOVO- 2021-00003, 2022-1.2.6-TET-IPARI-TR-2022-00023, 142877 FK22]; KDP-2021 Program for NG of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund [C1764415]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences [BO/00582/22/8] Funding text: The author(s) declare that financial support was received for the research and/or publication of this article. This research was funded by the 2023-1.1.1-PIACI_FOKUSZ-2024-00036, 2020-1.1.6-JOVO- 2021-00003, 2022-1.2.6-TET-IPARI-TR-2022-00023 and 142877 FK22, grant from the National Research, Development, and Innovation Office (NKFI), Hungary. This work was supported by the KDP-2021 Program for NG (C1764415) of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund. This work was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences BO/00582/22/8 (GJS). |
| Subjects: | R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 02 Sep 2025 14:30 |
| Last Modified: | 02 Sep 2025 14:30 |
| URI: | https://real.mtak.hu/id/eprint/223207 |
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