Rózsa, Péter and Homokiné Krafcsik, Olga and Czigány, Zsolt and Lenk, Sándor and Beke, Dávid and Gali, Ádám (2025) Thiolation and PEGylation of silicon carbide nanoparticles. RESULTS IN CHEMISTRY, 16. No.-102337. ISSN 2211-7156
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Abstract
In this study, we implement thiol termination on the surface of few-nanometer-sized silicon carbide (SiC) nanoparticles (NPs) to enable further applications, such as fluorescent biomarkers. Various spectroscopic techniques are employed to monitor the effectiveness of the surface treatment. A thiol-Michael addition reaction is performed by conjugating 4-arm PEGmaleimide molecules to the thiol groups of SiC NPs, further demonstrating the reactivity of thiol-terminated SiC NPs, which also acts as a protection layer against oxidation. These fluorescent thiolated SiC NPs, both with and without conjugated molecules, are directly applicable as bioinert probes. Since SiC NPs can potentially host room-temperature fluorescent defect quantum bits, our results are an important step to realize a bioinert, ultrasmall quantum sensor bioagents, which may open new avenues in biotechnology.
| Item Type: | Article |
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| Additional Information: | This study was supported by the Quantum Information National Laboratory sponsored by National Research, Development and Innovation Fund of Hungary (NKFIH) Grant No. 2022–2.1.1-NL-2022-00004 for the XPS and AFM investigations. The materials preparation was supported by the Ministry of Culture and Innovation of Hungary from NKFIH, financed under the TKP2021-NVA funding scheme (Project no. TKP2021-NVA-04). The HRTEM investigation was supported by the grant no. VEKOP-2.3.3-15-2016-00002 of the European Structural and Investment Funds. S. L. was supported by the Bolyai János Research Scholarship of the Hungarian Academy of Sciences and by the NKFIH grant ÚNKP-23-5-BME-448. The research reported in this paper and carried out at Wigner Research Centre for Physics is supported by the infrastructure of the Hungarian Academy of Sciences. |
| Uncontrolled Keywords: | Silicon carbide, Nanoparticle, Thiol termination, Thiol-Michael addition, Maleimide-PEG |
| Subjects: | Q Science / természettudomány > QC Physics / fizika > QC173.4 Material science / anyagtudomány |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 04 Sep 2025 11:30 |
| Last Modified: | 04 Sep 2025 11:30 |
| URI: | https://real.mtak.hu/id/eprint/223501 |
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