History of Alzheimer’s disease (AD) from the perspective of leading research theories

Bata, Zsófia and Horváth, András Attila (2021) History of Alzheimer’s disease (AD) from the perspective of leading research theories. KALEIDOSCOPE: MŰVELŐDÉS- TUDOMÁNY- ÉS ORVOSTÖRTÉNETI FOLYÓIRAT, 11 (23). pp. 143-151. ISSN 2062-2597

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Abstract

Alzheimer’s disease is the leading cause of cognitive deterioration. Alois Alzheimer described it for the first time in 1907. In the last five decades, there were emerging numerous hypotheses about the pathomechanism of this condition. The first one, the cholinergic hypothesis resulted in important antidementia medications. Amyloid cascade theory set the direction for many years in Alzheimer research. Currently, it also contributed to the licencing of a novel pharmaceutical Aducanumab. Additionally, the latest hypotheses shed light on the new aspects of the pathology of dementia. This study emphasizes the historical landmarks of Alzheimer’s research and reveals their interactions as well.

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