Kumar, Manjeet and Michael, Sushama and Alvarado-Valverde, Jesús and Zeke, András and Lazar, Tamas and Glavina, Juliana and Nagy-Kanta, Eszter and Donagh, Juan Mac and Kálmán, Zsófia Etelka and Pascarelli, Stefano and Palopoli, Nicolas and Dobson, László and Suarez, Carmen Florencia and Van Roey, Kim and Krystkowiak, Izabella and Griffin, Juan Esteban and Nagpal, Anurag and Bhardwaj, Rajesh and Diella, Francesca and Mészáros, Bálint and Dean, Kellie and Davey, Norman E and Pancsa, Rita and Chemes, Lucía B and Gibson, Toby J (2024) ELM—the Eukaryotic Linear Motif resource : 2024 update. NUCLEIC ACIDS RESEARCH, 52 (D1). D442-D455. ISSN 0305-1048
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Abstract
Short Linear Motifs (SLiMs) are the smallest structural and functional components of modular eukaryotic proteins. They are also the most abundant, especially when considering post-translational modifications. As well as being found throughout the cell as part of regulatory processes, SLiMs are extensively mimicked by intracellular pathogens. At the heart of the Eukaryotic Linear Motif (ELM) Resource is a representative (not comprehensive) database. The ELM entries are created by a growing community of skilled annotators and provide an introduction to linear motif functionality for biomedical researchers. The 2024 ELM update includes 346 novel motif instances in areas ranging from innate immunity to both protein and RNA degradation systems. In total, 39 classes of newly annotated motifs have been added, and another 17 existing entries have been updated in the database. The 2024 ELM release now includes 356 motif classes incorporating 4283 individual motif instances manually curated from 4274 scientific publications and including >700 links to experimentally determined 3D structures. In a recent development, the InterPro protein module resource now also includes ELM data. ELM is available at: http://elm.eu.org.
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| Additional Information: | Structuralãnd Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, 69117, Germany Collaboration for joint PhD degree between EMBLãnd Heidelberg University, Faculty of Biosciences, Germany Institute of Enzymology, HUN-REN Research Centre for Natural Sciences, Budapest, 1117, Hungary VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie, Pleinlaan 2, Brussels, 1050, Belgium Structural Biology Brussels, Department of Bioengineering, Vrije Universiteit Brussel, Pleinlaan 2, Brussels, 1050, Belgium Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (UNSAM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, CP 1650, Argentina Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín, Av. 25 de Mayo y Francia, Buenos Aires, San Martín, CP1650, Argentina Faculty of Information Technologyãnd Bionics, Pázmány Péter Catholic University, Práter u. 50 / A, Budapest, 1083, Hungary Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Bernal, Argentina Department of Computational Biology, University of Lausanne, Lausanne, Switzerland Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland Department of Bioinformatics, Semmelweis University, Tuzoltóu. 7, Budapest, 1094, Hungary Health Services Research, Sciensano, Brussels, Belgium Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Rd, Chelsea, London, SW3 6JB, United Kingdom Department of Biological Sciences, BITS Pilani, Goa K. K. Birla Goa campus, Zuarinagar, 403726, India Inselspital, University of Bern, Freiburgstrasse 15, Bern, CH-3010, Switzerland Signal Transduction Laboratory, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, Durham, NC 27713, United States Department of Structural Biology, Center of Excellence for Data Driven Discovery, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, United States School of Biochemistryãnd Cell Biology, University College Cork, 3.91 Western Gateway Building, Cork, Ireland Cited By :1 Export Date: 24 January 2024 CODEN: NARHA Correspondence Address: Kumar, M.; Structuralãnd Computational Biology Unit, Germany; email: manjeet.kumar@embl.de Correspondence Address: Pancsa, R.; Institute of Enzymology, Hungary; email: pancsa.rita@ttk.hu Correspondence Address: Chemes, L.B.; Instituto de Investigaciones Biotecnológicas, Argentina; email: lchemes@iib.unsam.edu.ar |
| Subjects: | Q Science / természettudomány > QR Microbiology / mikrobiológia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 16 Sep 2025 11:59 |
| Last Modified: | 16 Sep 2025 11:59 |
| URI: | https://real.mtak.hu/id/eprint/224310 |
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