Subclinical myocardial changes in rheumatoid arthritis: cardiovascular magnetic resonance evidence of immuno-inflammatory remodeling

Tarjanyi, Zoltan and Szabo, Liliana and Mong, Nikoletta and Mahmood, Adil and Dohy, Zsofia and Drobni, Zsofia Dora and Panajotu, Alexisz and Tothfalusi, Laszlo and Szappanos, Agnes and Raisi-Estabragh, Zahra and Merkely, Bela and Nagy, Gyorgy and Vago, Hajnalka (2025) Subclinical myocardial changes in rheumatoid arthritis: cardiovascular magnetic resonance evidence of immuno-inflammatory remodeling. FRONTIERS IN CARDIOVASCULAR MEDICINE, 12. ISSN 2297-055X

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Abstract

Objectives: Rheumatoid arthritis (RA) is associated with increased cardiovascular (CV) risk, yet the mechanisms remain unclear. This study aimed to evaluate myocardial structure, function, and tissue characterization using cardiovascular magnetic resonance (CMR) in RA patients and explore associations with RA disease severity. Methods: This mixed case-control study included 48 RA patients and 34 ageand sex-matched controls. RA patients were enrolled based on ACR/EULAR criteria, excluding other autoimmune diseases or significant coronary artery calcification. CMR assessed myocardial structure, function, and tissue characteristics, including native T1/T2 mapping, ventricular volumes, strain analysis, and late gadolinium enhancement. Linear regression models adjusted for age, sex, hypertension, and diabetes evaluated associations between RA characteristics and CMR parameters. Results: RA patients exhibited elevated native T1 values (980 ± 34 ms vs. 955 ± 33 ms; P < 0.01), indicative of subclinical myocardial fibrosis. Left ventricular global longitudinal strain (GLS) was reduced (22 ± 2% vs. 24 ± 3%; P < 0.01), and increased left ventricular mass and remodeling were observed. Right ventricular end-diastolic and end-systolic volume indices were lower in RA patients (RVEDVi: 68 ± 14 ml/m2 vs. 75 ± 12 ml/m2 , P = 0.02). Disease duration correlated negatively with GLS (β = −0.06, P < 0.05), while higher DAS28 scores were linked to reduced ejection fraction (β = −4.11, P < 0.05). Conclusions: This study demonstrates significant myocardial alterations in RA patients, including fibrosis, impaired systolic function, and ventricular remodeling, linked to disease severity. These findings highlight the need for early CV risk assessment and inflammation control to mitigate CV complications in RA.

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