Tőzsér, Petra and Kádár, Szabina and Szabó, Edina and Dobó, Máté and Tóth, Gergő and Balogh, György Tibor and Sóti, Péter and Sinkó, Bálint and Borbás, Enikő (2025) Comparison of lipophilic and size-exclusion membranes: the effect of stirring and cyclodextrin in the donor compartment. ADMET AND DMPK, 13 (4). No.-2753. ISSN 1848-7718
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Abstract
Background and purpose: The effective transport of an active pharmaceutical ingredient across various membrane systems is critical for enhancing its bioavailability, especially in formulations involving solubilizing agents. This study aims to investigate the permeability differences of carvedilol (CAR) between lipophilic and size-exclusion membranes in the presence of hydroxypropyl-beta-cyclodextrin (HP-β-CD) using in vitro side-by-side diffusion cell assays. Experimental approach: Solubility and permeability assays confirmed that HP-β-CD significantly enhanced the solubility of CAR, while simultaneously decreasing its permeability, indicating an interplay between the two parameters. Key results: A mathematical model based on Fick’s first law of diffusion was developed to describe drug transport across the UWL, and generally through the UWL-membrane system, with a particular focus on the role of solubilizing agents. Conclusion: Results from both the UWL and membrane limited transport conditions demonstrated that the supersaturation ratio (SSR, defined as the ratio of the drug concentration present in solution to its thermodynamic solubility measured in exactly the same media) between donor and acceptor compartments is the real driving force of the transport, when the complexing agent and the drug- HP-β-CD complex does not penetrate the membrane or the permeation of the solubilizing additive through the membrane is relatively slow, so it does not affect the transport of the API substantially.
| Item Type: | Article |
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| Additional Information: | Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, Hungary Semmelweis Egyetem, Department of Pharmaceutical Chemistry, Budapest, Hungary Semmelweis Egyetem, Center for Pharmacology and Drug Research & Development, Budapest, Hungary Budapest University of Technology and Economics, Department of Chemical and Environmental Process Engineering, Budapest, Hungary Lavet Pharmaceutical Ltd, Kistarcsa, Hungary Pion Inc., Billerica, United States Export Date: 29 August 2025; Cited By: 0 |
| Uncontrolled Keywords: | unstirred water layer, membrane transport, solubility, supersaturation ratio, carvedilol |
| Subjects: | R Medicine / orvostudomány > RM Therapeutics. Pharmacology / terápia, gyógyszertan |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 23 Sep 2025 13:08 |
| Last Modified: | 23 Sep 2025 13:08 |
| URI: | https://real.mtak.hu/id/eprint/224994 |
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