Csomos, Attila and Petrilla, Brigitta and Cseri, Levente and Turczel, Gábor and Steckel, Arnold and Matuscsák, Anett and Schlosser, Gitta (Vácziné) and Rózsa J., Balázs and Kovács, Ervin and Mucsi, Zoltán (2025) Introducing Rigidity into the GFP Chromophore via a Boron Bridge: Insights and Application in Two-Photon Imaging. ORGANIC LETTERS, 27. pp. 3128-3133. ISSN 1523-7060
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Abstract
A new family of azaborine fluorophores, consisting of ten compounds, has been developed that mimics the chromophore of green fluorescent protein, with conformation locked by a hydroxyboron bridge. These fluorophores exhibit fluorescence Stokes shifts up to 100 nm (0.56 eV) and high brightness (>104 M−1 cm−1 ) in the 408−525 nm range. Their potential utility for sensing applications was demonstrated by constructing zinc sensors capable of detecting 100 micromolar Zn2+ concentrations in biological systems with twophoton microscopy.
| Item Type: | Article |
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| Additional Information: | Femtonics Ltd., Budapest, H-1087, Hungary ELTE Hevesy György PhD School of Chemistry, Budapest, H-1117, Hungary BrainVisionCenter, Budapest, H-1094, Hungary NMR Research Laboratory, Centre for Structural Science, HUN-REN Research Centre for Natural Sciences, Budapest, H-1117, Hungary MTA-ELTE Lendület (Momentum) Ion Mobility Mass Spectrometry Research Group, Faculty of Science, Institute of Chemistry, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/A, Budapest, H-1117, Hungary Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Budapest, H-1117, Hungary The Faculty of Information Technology, Pázmány Péter Catholic University, Budapest, H-1083, Hungary Laboratory of 3D Functional Network and Dendritic Imaging, HUN-REN Institute of Experimental Medicine, Budapest, H-1083, Hungary University of Miskolc, Miskolc, H-3515, Hungary Export Date: 03 July 2025; Cited By: 0; Correspondence Address: B.J. Rózsa; BrainVisionCenter, Budapest, H-1094, Hungary; email: rozsa.balazs@koki.hu; E. Kovács; Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Budapest, H-1117, Hungary; email: kovacs.ervin@ttk.hu; Z. Mucsi; Femtonics Ltd., Budapest, H-1087, Hungary; email: zmucsi@femtonics.eu; CODEN: ORLEF |
| Subjects: | Q Science / természettudomány > QD Chemistry / kémia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 24 Sep 2025 13:03 |
| Last Modified: | 24 Sep 2025 13:03 |
| URI: | https://real.mtak.hu/id/eprint/225154 |
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