Tóth, Gergő Dániel and Koplányi, Gábor and Kenéz, Balázs and Balogh-Weiser, Diána (2023) Nanoformulation of Therapeutic Enzymes: A Short Review. PERIODICA POLYTECHNICA CHEMICAL ENGINEERING, 67 (4). pp. 624-635. ISSN 0324-5853 (print); 1587-3765 (online)
|
Text
11_PPCE_22826_P.pdf - Published Version Available under License Creative Commons Attribution. Download (690kB) | Preview |
Abstract
Enzyme replacement therapy (ERT) is a therapeutic approach that involves the administration of specific enzymes to the patient in order to correct metabolic defects caused by enzyme deficiency. The formulation of ERTs involves the production, purification, and formulation of the enzyme into a stable and biologically active drug product, often using recombinant DNA technology. Non-systemic ERTs often involve the immobilization of the enzyme on a carrier, such as hydrogels, liposomes, or nanoparticles. ERT holds great promise for the treatment of a wide range of genetic disorders, and its success regarding lysosomal storage diseases, such as Fabry disease, Gaucher disease, and Pompe disease has paved the way for the development of similar therapies for other genetic disorders too.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | therapeutic enzymes, nanoformulation, nanobiocatalyst |
| Subjects: | Q Science / természettudomány > QD Chemistry / kémia R Medicine / orvostudomány > RS Pharmacy and materia medica / gyógyszerészet, gyógyászati eszközök |
| Depositing User: | Dr. Diána Balogh |
| Date Deposited: | 03 Nov 2025 07:42 |
| Last Modified: | 03 Nov 2025 07:42 |
| URI: | https://real.mtak.hu/id/eprint/227903 |
Actions (login required)
 |
Edit Item |
