Evelopment of horse molecular genetics and the diagnostics of most important monogenic hereditary diseases

Sziszkosz, Nikolett and Jávor, András and Kusza, Szilvia (2016) Evelopment of horse molecular genetics and the diagnostics of most important monogenic hereditary diseases. ÁLLATTENYÉSZTÉS ÉS TAKARMÁNYOZÁS, 65 (3). pp. 71-81. ISSN 0230-1814

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Abstract

Horses (Equus caballus) are an early-domesticated species, and they have been selected for many traits during hundreds of years. Nowadays, novel gene-based approaches have started to replace initial phenotypic features in selecting strategies. Developing molecular biological techniques have made possible a better understanding of horse diseases at the genome-wide level. Identification of specific gene mutations, or polymorphisms, by modern molecular methods would be an effective, cheap, and rapid tool to detect new genetic features of traits and diseases. The main aim of the review is to introduce the most common monogenic diseases in horses. The general genetic basis and effects of novel methods in horse genetics have been introduced. Furthermore, the notable stages of horse genomic research have been summarized. Besides the genetic alterations, the important clinical symptoms, current therapies, and the possible opportunities for prevention have been underlined.

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