Interactions of the fusarium mycotoxins, fumonisin b1, deoxynivalenol and zearalenone.

Mariam, Kachlek and Szabó-Fodor, Judit and Kovács, Melinda (2017) Interactions of the fusarium mycotoxins, fumonisin b1, deoxynivalenol and zearalenone. ÁLLATTENYÉSZTÉS ÉS TAKARMÁNYOZÁS, 66 (3). pp. 181-195. ISSN 0230-1814

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Abstract

Multi-mycotoxin exposure is quite frequent since farm animals consume a mixture of commodities potentially contaminated with different types of mycotoxins. Combined toxicity has gained increased attention the last 15 years. In this review, the in vitro and in vivo combined toxicity studies of fumonisin B1 (FB1), deoxynivalenol (DON) and zearalenone (ZEN) have been summarised. The interactions revealed, varied from antagonism to synergism which can be attributed to different animals/cell lines, mycotoxin concentrations and mathematical designs used. However, addition and synergism occurred more often suggesting that animals are more adversely affected by the combined toxins than the single exposure. Fusarium mycotoxins are the most studied mycotoxins, yet there are few studies regarding their ternary mixtures. Thus more in vitro studies on ternary mixtures are needed with further confirmation of the effects by in vivo studies. In this fashion time and resources can be saved and animal welfare is respected as well.

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