Triglyceride-to-HDL-cholesterol Ratio as a Measure of Insulin Resistance in Obese Children and Adolescents

Panaika, Anna and Barkai, László (2025) Triglyceride-to-HDL-cholesterol Ratio as a Measure of Insulin Resistance in Obese Children and Adolescents. EGÉSZSÉGTUDOMÁNYI KÖZLEMÉNYEK, 15 (2). pp. 5-12. ISSN 2063-2142

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Abstract

Childhood obesity is associated with insulin resistance, type 2 diabetes, and metabolic syndrome. Although accurate, traditional insulin measurement techniques are not practical for routine clinical usage in pediatric populations. This study investigates whether the ratio of triglycerides to HDL cholesterol can be used as a straightforward indicator of insulin resistance in obese children and adolescents. A retrospective study of 123 obese people aged 5 to 19 years discovered a moderate but substantial positive relationship between this ratio and insulin resistance, as evaluated by HOMA-IR. Higher ratios were associated with higher HOMA-IR readings and insulin levels. The triglyceride-to-HDL ratio may therefore provide a useful substitute for evaluating insulin resistance in clinical contexts, although more investigation is needed to validate its applicability in larger populations.

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