Perspectives on the Combined Application of Bacteriophages and Phytoseptics for Overcoming Antimicrobial Resistance in In Vitro Studies

Kolesnyk, Oleh and Kryvtsova, Marina and Hörcsik, Tibor Zsolt and Csabai, Judit (2025) Perspectives on the Combined Application of Bacteriophages and Phytoseptics for Overcoming Antimicrobial Resistance in In Vitro Studies. In: Fenntartható Tájgazdálkodási Tudományos Műhely konferenciája 2025 : Innovatív megoldások a XXI. század mezőgazdaságában. Nyíregyházi Egyetem, Műszaki és Agrártudományi Intézet, Nyíregyháza, pp. 142-146. ISBN 9786156032836

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Abstract

Antimicrobial resistance is increasingly complex to treat with single antibiotic therapies. As new strains continue to develop, scientists look towards other solutions that have multiple modes of action. Among the greatest hopes are bacteriophages and plant-based antimicrobial agents (phytoseptics). This article reviews current results on the solo and combined actions of these two technologies. In vitro studies have revealed that bacteriophages exhibit target-specific efficacy against multiple clinical strains of bacteria, although their efficacy is often strain-specific. Plant extracts, in contrast, exhibited broader antimicrobial activity and additional anti-inflammatory and antioxidant properties. In combined use, multiple instances implied a synergistic interaction between phages and phytochemicals that augments therapeutic opportunity with reduced side effects. These findings bode well for the development of multifaceted treatment regimes that incorporate natural and biological agents to counter the rise in antibiotic resistance and refine clinical outcomes.

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