Csécsei, Péter and Takács, Bertalan Vilmos and Pasitka, Lídia and Várnai, Réka and Péterfi, Zoltán and Orbán, Brigitta and Czabajszki, Máté and Oláh, Csaba Zsolt and Schwarcz, Attila (2025) Distinct Gut Microbiota Profiles in Unruptured and Ruptured Intracranial Aneurysms: Focus on Butyrate-Producing Bacteria. JOURNAL OF CLINICAL MEDICINE, 14 (10). No. -jcm14103488. ISSN 2077-0383
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Abstract
Background: Gut microbiome composition may influence the risk of intracranial aneurysm rupture. Methods: This study analyzed the gut microbiota of 48 patients—24 with ruptured aneurysms (RA) and 24 with unruptured intracranial aneurysms (UIA)—using next-generation sequencing. Results: While alpha diversity was similar between groups, beta diversity revealed significant taxonomic differences (Bray–Curtis: p = 0.02; unweighted UniFrac: p = 0.0291). Both groups were dominated by the phyla Bacillota, Bacteroidota, and Proteobacteria, but genus- and family-level differences were observed. RA patients showed higher abundances of Anaerotruncus, Coprobacillus, Sellimonas, Hungatella, and Ruthenibacterium, whereas UIA patients exhibited greater levels of Faecalibacterium, Brotolimicola, Clostridiaceae, Roseburia, and Agathobaculum. Linear discriminant analysis identified one class, 10 genera, and 17 species that differed significantly between groups. Notably, Faecalibacterium prausnitzii and Agathobaculum butyriciproducens—bacteria known for their anti-inflammatory and neuroprotective properties—were enriched in UIA patients. Conclusions: These findings suggest that gut microbiota, particularly short-chain fatty acid–producing bacteria, may contribute to vascular protection and aneurysm pathophysiology. Microbiome-based therapeutic strategies could offer new avenues for the prevention of cerebrovascular disease.
| Item Type: | Article |
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| Additional Information: | Department of Neurosurgery, Medical School, University of Pecs, Pecs, 7622, Hungary HCEMM-HUN-REN BRC Mutagenesis and Carcinogenesis Research Group, Institute of Genetics, HUN-REN Biological Research Centre, Szeged, 6726, Hungary Faculty of Science and Informatics, Doctoral School of Biology, University of Szeged, Szeged, 6720, Hungary Delta Bio 2000 Ltd., Szeged, 6726, Hungary Department of Dentistry, Oral and Maxillofacial Surgery, Medical School, University of Pecs, Pecs, 7622, Hungary Department of Primary Health Care, Medical School, University of Pecs, Pecs, 7622, Hungary 1st Department of Medicine, Medical School, University of Pecs, Pecs, 7622, Hungary Department of Neurosurgery, Borsod-Abaúj-Zemplén County Center Hospital, University Teaching Hospital, Miskolc, 3526, Hungary Export Date: 30 June 2025; Correspondence Address: P. Csecsei; Department of Neurosurgery, Medical School, University of Pecs, Pecs, 7622, Hungary; email: csecseipeti@yahoo.com |
| Uncontrolled Keywords: | aneurysmal subarachnoid hemorrhage; gut microbiome; short-chain fatty acids |
| Subjects: | R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC685 Diseases of the heart, Cardiology / kardiológia R Medicine / orvostudomány > RM Therapeutics. Pharmacology / terápia, gyógyszertan |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 10 Feb 2026 12:45 |
| Last Modified: | 10 Feb 2026 12:45 |
| URI: | https://real.mtak.hu/id/eprint/233653 |
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