Tóth, Zsejke-Réka and Feraru, Alexandra and Saszet, Kata and Veréb, Gábor and Vodnar, Dan C. and Todea, Milica and Timar-Gabor, Alida and Dave, Aditi K. and Sand, Denisa and Dreanca, Alexandra and Magyari, Klára and Baia, Lucian (2025) Relation between shape-tailored CeO2 nanoparticles morphology and hemocompatibility and antimicrobial effect. BIOMATERIALS ADVANCES, 171. No. 214229. ISSN 2772-9516
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Abstract
Cerium is one of the most studied rare elements whose oxidative state (Ce3+ and Ce4+) can be changed in different environments. Cerium oxide nanoparticles (CeO2 NPs), which are nevertheless more complex chemical structures, are nowadays very exciting entities involved in the biomedical field, particularly in the four stages of wound healing. In the first stage, called hemostasis, several issues such as the required morphology to be biologically efficient, and the effect of Ce3+ and Ce4+ on the applicability potential of CeO2 NPs remain unclear. Our interest is focused in this study on the detailed understanding of the cations' location, when differently shaped CeO2 NPs (i.e., nanocube, nanosphere, nanorod, and polyhedral particles) were used. Additionally, the present research highlights the applicability of nanoparticles in direct contact with blood and the antibacterial and antifungal properties of the samples. A correlation between the fungicidal properties of the samples and the Ce3+ cations formed on the surface was performed. The nanosphere/nanorod particles show the highest interaction with the hemoglobin (Hb). In addition, it was concluded that negatively charged surfaces favor the antibacterial properties using gram-negative bacteria. The morphologies' applicability will depend on the following parameters: surface area/volume ratio, crystallinity, hydrophilicity, Ce3+/Ce4+ ion distribution, and surface charge. Considering all these parameters and the nanoparticle applications, the nanorod will be the most suitable for antimicrobiological applications (antibacterial and antifungal), and showing the highest hemocompatibility. © 2025 The Authors
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| Additional Information: | Interdisciplinary Research Institute on Bio-Nano-Sciences, Babeș-Bolyai University, Treboniu Laurian str. 42, Cluj-Napoca, RO-400271, Romania Doctoral School in Physics, Faculty of Physics, Babeș-Bolyai University, M. Kogălniceanu str. 1, Cluj-Napoca, RO-400084, Romania Department of Biosystem Engineering, Faculty of Engineering, University of Szeged, Moszkvai Blvd. 9, Szeged, H-6725, Hungary Faculty of Food Science and Technology, University of Agricultural Science and Veterinary Medicine, Calea Mănăștur 3-5, Cluj-Napoca, RO-400372, Romania Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Victor Babeş 8, Cluj-Napoca, RO-400012, Romania Faculty of Environmental Sciences and Engineering, Babeș Bolyai University, Fântânele 30, Cluj-Napoca, RO-400535, Romania Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 3-5 Calea Manastur, Cluj-Napoca, RO-400372, Romania INSPIRE Research Platform InfoBioNano4Health & Biomedical Imaging, Babeș Bolyai University, Arany Janos 11, Cluj-Napoca, 400084, Romania Faculty of Physics, Babeș-Bolyai University, M. Kogălniceanu str. 1, Cluj-Napoca, RO-400084, Romania Export Date: 3 March 2025 Correspondence Address: Magyari, K.; rdisciplinary Research Institute on Bio-Nano-Sciences, Treboniu Laurian str. 42, Romania; email: klara.magyari@ubbcluj.ro Funding details: European Social Fund Plus, ESF Funding details: Universitatea Babeș-Bolyai, POCU/993/6/13/153310, 21PFE/ 30.12.2021, PFE-550-UBB Funding details: Mount Allison University, MTA, Domus 153/10/2022/HTMT Funding text 1: Zs.-R. T\\u00F3th expresses her thanks to the Babe\\u0219-Bolyai University Postdoctoral Advanced Fellowship program with the following project number: nr. 21PFE/ 30.12.2021 , ID: PFE-550-UBB. The Development of Advanced and Applicative Research Competencies in the Logic of STEAM + Health\\u201D/POCU/993/6/13/153310, a project co-financed by the European Social Fund through The Romanian Operational Programme Human Capital 2014-2020. Zs.-R. Toth acknowledges the financial support of MTA Domus 153/10/2022/HTMT . The authors thank Lilla N\\u00E1nai and \\u00C1ron \\u00C1goston for the TEM and DLS measurements. |
| Uncontrolled Keywords: | HEMOSTASIS; BACTERIA; ANTIBACTERIAL; HEMOGLOBIN; NANOPARTICLES; ANTIFUNGAL; ANTIBACTERIALS; NANORODS; Haemostasis; Antibacterial properties; Anti-microbial effects; Antifungals; Nanospheres; Haemocompatibility; Cerium oxide; Cerium oxides; Nanoparticle morphology; CeO 2; Ce 3+; Cerium-oxide; |
| Subjects: | Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 12 Feb 2026 09:20 |
| Last Modified: | 12 Feb 2026 09:20 |
| URI: | https://real.mtak.hu/id/eprint/233839 |
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