Enantioselective Catalytic Three-Component Synthesis of Optically Active Propargyl Amino Ethers

Talybov, Gulahmad Mirahmad (2025) Enantioselective Catalytic Three-Component Synthesis of Optically Active Propargyl Amino Ethers. HUNGARIAN JOURNAL OF INDUSTRY AND CHEMISTRY, 53 (1). pp. 39-42. ISSN 0133-0276

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Abstract

Catalytic enantioselective three-component aminomethylation of benzaldehyde as well as its methoxy-substituted derivatives and propargyl ethers with aniline in the presence of a chiral catalyst – pseudoephedrine – yielded previously unknown optically active propargyl amino ethers with high yields and a high degree of enantioselectivity. This reaction can also be used to form both C-C and C-N bonds.

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