Ligands of purinergic receptors stimulate electrogenic H⁺ transport of neutrophils

Susztak, Katalin and Káldi, Krisztina and Kapus, András and Ligeti, Erzsébet (1995) Ligands of purinergic receptors stimulate electrogenic H⁺ transport of neutrophils. FEBS LETTERS, 375 (1-2). pp. 79-82. ISSN 0014-5793

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Abstract

The possible role of ATP, acting as a ligand on cell surface receptor was investigated in the activation of the electrogenic H+-transporting pathway of porcine neutrophil granulocytes. (1) ATP brought about 2.1-fold increase in the rate of H+-efflux. (2) The order of potency of different nucleotides suggests, that ATP acts on P2 type purinoceptor. (3) The effect of the nucleotides was prevented by inhibition of phospholipase A 2. (4) Inhibition of the metabolism of arachidonic acid (AA) via the cyclooxygenase pathway had no effect, whereas inhibition of the lipoxygenase pathway significantly enhanced H÷-release. This is the first report about activation of the H+-transporter by physiological stimulator acting on the cell surface.

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