Detailed Physicochemical Analysis of Hyaluronic Acid and Transferrin Self-Assembly To Produce Drug Carrier Colloids

Seres, László and Varga, Norbert and Torma, Bianka and Juhász, Ádám and Csapó, Edit (2025) Detailed Physicochemical Analysis of Hyaluronic Acid and Transferrin Self-Assembly To Produce Drug Carrier Colloids. ACS OMEGA, 10 (46). pp. 56520-56532. ISSN 2470-1343

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Abstract

Polyelectrolyte complexes (PECs) are polymeric nanostructurescreatedbytheself-assemblyofoppositelycharged macromolecules.PEC-basednovelbiomaterialsarecurrentlybeing researchedascontrolleddrugdeliveryvehiclesduetotheirunique combinationofbeneficialproperties. Inthiswork, theformationof a newcolloid systemcomposedof human apo-transferrin (Tr) protein andhigh-molecular-weight hyaluronic acid (HyA) polysaccharidewasstudiedfromnumerousperspectivesbecause, tothe bestof our knowledge, no information is available regarding this PEC-based Tr-HyA formula. For detailed characterization, the experimental results of several physicochemical and colloid chemistry techniques, suchas light scattering, rheology, titrationmicrocalorimetry, andelectronmicroscopy, were analyzed. It was emphasized that thepHandmass ratioof themacromolecules greatly influence the self-assemblyprocess. Particleswith enhancedstabilitywerepreparedataTr/HyA=2:1massratio.Theapplicabilityofthesecolloidparticleswithadiameterof240− 260nmasdrugdeliveryvehicleswas evaluatedbyencapsulating several practicallywater-insolublemolecules to increase their solubilityinwater.Wehighlightedthatthenanoformulationrevealedca.3timesbettersolubilityandenhancedreleaseforvitamins D3andK1comparedtotheunformulatedones.

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