Comparative analysis of two lateral flow immunoassays for carbapenemase detection in Klebsiella pneumoniae and Pseudomonas aeruginosa

Yıldız, Serap Süzük and Arıcasoy, Özge Nur and Bakkaloğlu, Zekiye and Ünaldı, Özlem and Hekimoğlu, Can Hüseyin and Güreser, Ayşe Semra and Mumcuoğlu, İpek and Dal, Tuba (2026) Comparative analysis of two lateral flow immunoassays for carbapenemase detection in Klebsiella pneumoniae and Pseudomonas aeruginosa. ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 73 (1). pp. 54-58. ISSN 1217-8950

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Abstract

Accurate and rapid identification of carbapenemase-producing Gram-negative bacteria is essential for appropriate antimicrobial therapy and infection control. This study compared the diagnostic performance of two multiplex lateral flow immunoassays, the NG-Test CARBA 5 (NG) and a Colloidal Gold Immunoassay (CGI), for the detection of major carbapenemases in clinical isolates of Klebsiella pneumoniae and Pseudomonas aeruginosa . A total of 100 non-duplicate carbapenem-resistant isolates collected in 2024 were included. An in-house polymerase chain reaction assay targeting bla KPC , bla NDM , bla VIM , bla IMP , and bla OXA-48-like genes served as the reference standard.

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