Recent advances on cyclization reaction of indole-tethered alkenes for the construction of polyheterocycles

Haibo, Mei and Semghouli, Anas and Kiss, Loránd and Han, Jianlin (2026) Recent advances on cyclization reaction of indole-tethered alkenes for the construction of polyheterocycles. CHINESE CHEMICAL LETTERS. No. 112405. ISSN 1001-8417

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Abstract

Indole-containing polyheterocycles belong to an extremely important class of organic compounds, and the related skeletons are found in many natural products and bioactive molecules. They play an important role in synthetic and medicinal chemistry, agrochemicals, and advanced materials. Moreover, they also serve as versatile building blocks and tools for constructing more complex molecules. Thus, development of efficient methods for assembly of indole-containing polyheterocycles has attracted considerable attention in recent years. The aim of this review is to summarize recent developments in the synthesis of indole-fused or spired polycyclic compounds via cyclization of indole-tethered alkenes. Indole-tethered alkenes with alkenyl species linked to different position of indole moiety is presented.

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