Simple and choice reaction times are prolonged following extracorporeal circulation : a potential method for the assessment of acute neurocognitive deficit

Ajtay, Zénó and Kellényi, Loránd and Hejjel, László and Solymos, Andor and Németh, Ádám and Bártfai, Imre and Kovács, Norbert and Cziráki, Attila and Papp, Lajos (2009) Simple and choice reaction times are prolonged following extracorporeal circulation : a potential method for the assessment of acute neurocognitive deficit. MEDICAL SCIENCE MONITOR-INTERNATIONAL MEDICAL JOURNAL FOR EXPERIMENTAL AND CLINICAL RESEARCH, 15 (9). CR470-CR476. ISSN 1234-1010

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Abstract

Cognitive deficit related to open heart surgery came into the focus of interest according to professional and social expectations. The negative effects on quality of life and the large number of involved patients emphasize its investigation. The bed-side measurement of simple and choice reaction time (sRT and cRT) has the objectivity of cortical evoked potential analysis; however there is no need for EEG instrumentation and laboratory. This is a functional assessment similarly to neuropsychological tests, but requires significantly shorter time, and is less demanding for the patient. We found a statistically significant positive correlation of sRT and cRT elongation and perfusion time. At the same time there were no statistically significant changes of mean sRT and cRT values before (sRT: 208±54 s, cRT: 369±59 s) and after (sRT: 229±67 s, cRT: 392±105 s) the surgery probably due to the inhomogeneous patient population. The weak correlation (coefficients: 0.1418-0.8484) for sRT and cRT changes as a function of perfusion time confirm the presence of other factors of postoperative brain damage. The investigated bed-side test is clinically feasible, simple and can be completed within 30 minutes. Further studies are encouraged to compare above method to other tests in a larger, stratified cardiac surgery population

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